Oral Pain Relief Medications

Search the internet looking for effective remedies or painkillers for toothache pain. Several articles from major publications say that over-the-counter anti-inflammatory drugs such as ibuprofen, Advil, Motrin, or naproxen work best for dental pain because they reduce inflammation. However, if you ever have a toothache, you know they are full of shit! While these are especially useful because of their inflammation-reducing benefits, they fall short. More often than not, your best choice is over-the-counter pain relief. These come in liquid, gels, creams, and swabs form and can be used for temporary pain management. These products usually contain an active ingredient such as benzocaine that temporarily numbs the area until you can see a dentist. Take a look at 249 Smile’s selection of over-the-counter oral pain relief medications. These were voted the best by you, the consumers!

SaleBestseller No. 1

Orajel 4X for Toothache & Gum Pain: Severe Cream Tube 0.33oz- From Oral Pain Relief Brand

INSTANT PAIN RELIEF: Instant pain relief with Orajel’s unique 4X clinical strength formula to help relieve pain of the tooth and gums
4X ACTIVE INGREDIENTS: With 4 active ingredients, Orajel Cream provides fast acting and maximum strength relief when you need it most
KILLS HARMFUL BACTERIA: Unique formula is designed to help kill harmful bacteria in the mouth, and can help to prevent infections

SaleBestseller No. 2

Orajel 3X for Toothache & Gum Pain: Maximum Gel Tube 0.42oz - From #1 Oral Pain Relief Brand - Orajel for Instant Pain Relief

INSTANT PAIN RELIEF: Instant pain relief with Orajel’s maximum strength formula to help relieve pain of the tooth and gums with 20% benzocaine
KILLS HARMFUL BACTERIA: Unique formula is designed to help kill harmful bacteria in the mouth, and can help to prevent infections
COOLING RELIEF: To help relieve gum irritation, Orajel toothache gel contains cooling relief

SaleBestseller No. 3

DenTek Instant Oral Pain Relief Maximum Strength Kit for Toothaches | 50 Count

DenTek Instant Pain Relief, Advanced Kit gives instant and precise relief from oral pain and toothaches
Ergonomic handle to reach any area of the mouth gives simple, no-fingers no-mess, relief
Fresh Mint flavored Benzocaine relieves tooth pain, sore gums and mouth sores

Bestseller No. 4

Anbesol Maximum Strength Oral Pain Relief Gel, Instant Pain Relief for Toothache Pain, Canker Sores, Sore Gums, Mouth Sores, Denture Pain, and Aligner Pain, ADA Accepted, 0.33 oz (Packaging May Vary)

The information below is per-pack only
Instant Oral Pain Relief: Anbesol Maximum Strength gel for mouth pain, including toothache pain, canker sores, sore gums, mouth sores, denture pain, braces, retainer, and aligner pain, and minor dental procedures
OW to WOW! Instantly: Formulated with the active ingredient Benzocaine, an oral pain reliever, and numbs instantly to temporarily relieve toothaches, gum pain, canker sores and aligner pain

Bestseller No. 5

Anbesol Maximum Strength Oral Anesthetic Liquid - 0.41 fl oz (packaging may vary)

Instant Oral Pain Relief: Anbesol Maximum Strength Liquid for mouth pain, including toothache pain, canker sores, sore gums, mouth sores, denture pain, braces, retainer and aligner pain, and minor dental procedures
OW to WOW! Instantly: Formulated with the active ingredient Benzocaine, an oral pain reliever, and numbs instantly to temporarily relieve toothaches, gum pain, canker sores and aligner pain.
Liquid Formula: Anbesol Liquid Formula goes on clear and is undetectable, stays where you apply it, and provides fast and effective numbing of oral pain

SaleBestseller No. 6

Orajel 3X for Mouth Sores: Maximum Strength Gel Tube 0.42oz- From #1 Oral Pain Relief Brand

INSTANT PAIN RELIEF: Orajel Mouth Sore Gel contains 20% Benzocaine to relieve pain from canker sores, mouth sores, cold sores and other mouth irritations
SOOTHING RELIEF: Maximum strength gel uses menthol to soothe irritated and sore gums quickly, where you need it most
PROTECTION: Our unique, fast acting, formula contains an astringent to help protect sores from irritation, including irritation from dentures or braces, as well as canker sores

SaleBestseller No. 7

Orajel Nonseptic Mouth Sore Rinse 16oz, Soothing Mint Flavor, Provides Pain Relief, Promotes Healing, 3-Pack

PAIN RELIEF: Orajel Mouthwash helps to provide you with temporary pain relief from your mouth sores and irritation.
PROMOTES HEALING: Specially formulated to help kill bacillus in your mouth and promote healing so you can feel better.
FOR ALL MOUTH SORES: From canker sores, to cheek bites, gum irritation, and sores from dentures or braces- Orajel Mouth Sore Rinse can help alleviate your pain from the comfort of your home.

Bestseller No. 8

Rite Aid Maximum Strength Liquid Anesthetic Oral Pain Relief - .5 fl oz, Benzocaine 20% | Pain Relief Medications & Treatments | Canker Sore and Tooth Pain Relief for Adults | Mouth Sores Treatment

MOUTH SORE TREATMENT: Rite Aid Max Strength Oral Liquid Anesthetic Benzocaine 20% pain relieving liquid temporarily relieves pain associated with toothaches, sore gums, mouth sores, canker sores, dentures/braces, cheek bites, and minor dental procedures.
FAST-ACTING PAIN RELIEF: Rite Aid offers instant relief from pain associated with toothaches, gum pain, canker sores, and dentures/braces. Compare Rite Aid to the leading national brand and get the same reliable mouth pain relief you can count on.
MAXIMUM STRENGTH: Formulated with 20% Benzocaine, Rite Aid Maximum Strength Liquid Anesthetic Oral Pain Relief offers the maximum amount of pain relief and aims to temporarily relief the mouth and tooth pain that ails you, so you can live pain free.

Bestseller No. 9

Benzodent Dental Pain Relieving Cream for Dentures and Braces, Topical Anesthetic, 0.25 Ounce Tube

Maximum Strength of Benzocaine
For oral discomfort

Bestseller No. 10

DenTek Instant Oral Pain Relief Maximum Strength Kit for Toothaches | 50-Count per pack | 2-Pack

2-Pack. Each pack includes one bottle of Benzocaine (20%), 50-Count Disposable Applicators, Applicator Handle, and a Carrying Case.
Get instant relief from severe toothaches with Maximum Strength DenTek Instant Oral Pain Relief.
No fingers, No mess. Single-use disposable applicators. Dentist Recommended.

Bestseller No. 11

Rite Aid Severe Toothache and Gum Relief - 0.25 oz

MOUTH SORE TREATMENT: Rite Aid Severe Toothache & Gum Relief Benzocaine 20% pain relieving gel temporarily relieves pain associated with toothaches, sore gums, mouth sores, canker sores, dentures/braces, cheek bites, and minor dental procedures.
FAST-ACTING PAIN RELIEF: Rite Aid offers instant relief from pain associated with toothaches, gum pain, canker sores, and dentures/braces. Compare Rite Aid to the leading national brand and get the same reliable mouth pain relief you can count on.
FOR SEVERE PAIN: Formulated with 20% Benzocaine, Menthol 0.5%, and Zinc Chloride 0.15%, Rite Aid Rite Aid Severe Toothache & Gum Relief offers the maximum amount of pain relief and aims to temporarily relief the mouth and tooth pain that ails you.

Bestseller No. 12

Orajel 2X Medicated Toothache & Mouth Sores Liquid, 0.45 Fl Oz

20% Benzocaine to relieve oral pain
Menthol to soothe gums
Fast-acting liquid for instant pain relief

SaleBestseller No. 13

Canker-X Mouth Sore Gel, Fast Pain Relief & Healing for Canker Sores, Cheek Bites and Oral Abrasions, Oral Pain Relief Gel, Benzocaine-Free and Alcohol-Free, Adults and Kids 6+ Years, 0.28 fl oz

FAST PAIN RELIEF & HEALING GEL: Canker-X canker sore treatment gel provides fast, long-lasting oral pain relief from canker sores, abrasions and more without any burning or numbing sensation. Clinically tested formula with NO Benzocaine and NO alcohol
MOUTH SORES TREATMENT: Canker-X soothes canker sores, cheek bites, mouth sores and mouth abrasions often caused by braces and dentures. The alcohol-free and benzocaine-free oral pain relief gel promotes healing and relieves pain
SOOTHES, HYDRATES & PROTECTS: The unique and clinically tested Canker-X gel formula contains Polyvinylpyrrolidone (PVP) which forms a micro-thin protective coating over a mouth sore to block irritants like food & drinks, and relieves discomfort for up to 6 hours

Bestseller No. 14

Zilactin-B Fast Acting Canker Sore Treatment - Long Lasting Protection and Oral Pain Relief of Canker Sores, Mouth Sores and Gum Irritations, Made in USA, 0.25oz Gel, Pack of 1

Broad-Spectrum Formula: Provides immediate, long lasting oral pain relief of canker sores, mouth sores and gum irritation
Fast, Long-Lasting Relief: Contains a proprietary blend of ingredients including 10% Benzocaine for immediate, long lasting, oral pain relief
Bioadhesive Technology: Provides up to 6 hours of durable protection and relief so you can eat and drink pain free

Bestseller No. 15

Gengigel Hyaluronic Acid Oral Spray for Mouth & Gum Discomfort (20 ml), Soothes Irritation, Promotes Natural Healing & Protects Delicate Oral Tissue, No Paraben or SLS, Vegan & Kosher

On-The-Go Targeted Relief: Gengigel Hyaluronic Acid Oral Spray helps alleviate pain from mouth ulcers, bleeding gums, and minor wounds. Formulated with hyaluronic acid, it helps restore gum health and reduce discomfort around dental implants
Soothes, Heals & Protects: It soothes pain, forms a protective barrier over oral tissues, and promotes healing by speeding up recovery from minor issues, damaged or bleeding gums, food burns, and oral abrasions. Helps maintain good oral health
Suitable for Daily Use: Gengigel is vegan, kosher, and is a safe option for daily oral care, offering relief from gum problems, and irritation caused by braces, dentures, or aligners. Formulated without SLS, gluten, triclosan, parabens, and lactose

Bestseller No. 16

Anadent Toothache Gel, 20% Benzocaine Oral Gel for Instant Pain Relief, Oral and Toothache Medicine for Severe Pain, Fast Acting Relief of Cavity and Canker Sores, 0.25oz

Benzocaine Oral Gel: The toothache gel contains 20% benzocaine oral gel which is a highly effective active ingredient that gives precise and instant relief for oral discomfort and toothache pain caused by dentures or sores.
Fast Acting Relief: Using Anadent toothache gel, you'll experience the fast acting relief of toothache pains with the strength of benzocaine. It can also help you to dull the pain long enough for you to fall asleep.
Toothache Medicine for Severe Pain: This toothache medicine is a cure for almost everything. It promotes the healing of canker sores and can help relieve cavities, tooth pains, sore gums, oral pains, gum pains, and mouth sores.

Bestseller No. 17

DOLODENT Tooth Pain Relief for Adults – 15 ml Tooth Ache Drops – Natural Oral Pain Relief for Toothaches, Sore Gums and Braces Irritation – Easy to Apply - Anti-Inflammatory Dental Drops

PAIN RELIEF SOLUTION: Dental and gum pain is never easy to handle. Luckily, the DOLODENT tooth pain drops are a quick and easy solution to relieve some of the pain caused by toothaches, sore gums, and brace irritation.
NATURAL FORMULA: Our toothache drops are formulated with powerful natural ingredients that can help numb the pain and make you feel better. These dental drops contain arnica montana, asafoedida, chamomilla, hecla lava, and hypercum.
WIDE ACTION: The DOLODENT toothache drops can be used to calm down the pain caused by irritation and infection. They are an all-natural solution for teeth pain, check swelling, bone pain, and neuralgia.

Bestseller No. 18

Orajel Maximum Strength Nighttime Toothache Pain Relief Cream - 0.25 Oz

B00433JHW2

Bestseller No. 19

Dynamic Dental Candi Caine, Topical Anesthetic Gel, 1 oz, Bubble Gum Flavor

20% Topical Anesthetic Gel - Our numbing gel comforts patients with wounds, and irritations and provides temporary relief of pain during procedures including injections, periodontal curettage, scaling, and intra-oral radiography.
Quicky Topical Comfort - Even at home you can use our CandiCaine gel to help alleviate tooth discomfort until reaching the dental office. It usually takes about 5 to 6 seconds for the numbing sensation to appear.
Suitable for Kids - Our topical gel works for teething aches and helps kids overcome dentist fear. Is it recommended to use only on adults and children 2 years and older. Available in 7 delicious flavors with no bitter aftertaste: Bubble Gum, Cherry, Grape, Mint, Piña colada, Raspberry & Strawberry.

SaleBestseller No. 20

Kank-A Soft Brush Tooth & Mouth Pain Gel, Professional Strength, 0.07 Ounce, Dual Relief Formula for Toothaches, Gum & Other Mouth Pain, Easy to Use Pen Applicator, Fast-Acting Pain Relief

Softbrush Pain Gel
Delivers medication in a pleasant tasting gel
Combines maximum pain relief with a potent oral astringent for fast relief from ill-fitting oral appliances, toothaches, or minor gum irritation

Choosing Oral Pain Relief Products

Oral pain can be a debilitating and distressing experience, affecting our capability to speak, eat and enjoy daily activities. Whether it is gum inflammation, toothache, or mouth sores, finding successful relief is vital for restoring comfort and oral health. Fortunately, many oral pain relief products are accessible on the market, ranging from over-the-counter medications to natural remedies. Anyway, picking the perfect product can be overwhelming, considering the wide range of options. In this essential guide, we will explore essential factors to consider when choosing oral pain relief products, empowering you to make informed decisions for the best oral care. Here is a complete guide on picking oral pain relief products:

Consider the pain type you are experiencing.

Different types of oral pain need different kinds of pain relief. For example, toothache pain is generally treated with over-the-counter pain relievers, such as acetaminophen or ibuprofen. Gum disease pain may need a prescription drug, such as antibiotics.

Think about your full health.

If you have any health situations, such as kidney or liver disease, you may need to reject certain pain relievers. Be sure to discuss with your doctor about which pain relievers are safe for you to take.

Read the reviews

There are many sites where you can read reviews of oral pain relief items. This can be a supportive way to get an idea of which products are most successful and have fewer bad effects.

Talk to your pharmacist or doctor

If you are still not sure about which oral pain relief product is best for you, discuss it with your pharmacist or doctor. They can help you pick a product that is effective and safe for you.

Consider the dosage

Over-the-counter pain relievers come in a range of dosages. Be sure to read the label perfectly and follow the instructions. If you are taking a prescription drug, be sure to take it as directed by your doctor.

Last update on 2025-04-03 at 04:00